Seksuell aktivitet kan være ekstra belastende for hjertet. Dersom du har hjerteproblemer eller tror du kan ha et hjerteproblem er det viktig at du opplyser om dette i samtalen med farmasøyten i apotek.

The necessarily mean steady point out volume of distribution (Vss) for sildenafil is one zero five L, indicating distribution into your tissues. Sildenafil and its important circulating N-desmethyl metabolite are the two around ninety six% certain to plasma proteins. Protein binding is impartial of total drug concentrations.

Clients who exhibit hemodynamic instability on alpha-blocker therapy by yourself are at amplified threat of symptomatic hypotension with concomitant utilization of PDE5 inhibitors. Sufferers must be steady on alpha-blocker therapy before initiating a PDE5 inhibitor.

are allergic to sildenafil, as contained in VIAGRA and REVATIO, or any from the elements in VIAGRA. See the conclude of this leaflet for a whole listing of elements in VIAGRA.

Pregnancy. It's not necessarily regarded if or how sildenafil could affect pregnancy or harm an unborn little one. Explain to your Health care supplier When you are or approach to become pregnant.

In wholesome male volunteers, there was no proof of the clinically substantial effect of azithromycin (500 mg day by day for three days) to the systemic publicity of sildenafil or its main circulating metabolite.

Scientific info have revealed that co-administration with saquinavir or erythromycin greater plasma levels of sildenafil by about 3 fold [see DRUG INTERACTIONS and Medical PHARMACOLOGY].

There won't be any managed clinical facts on the safety or efficacy of VIAGRA in clients with retinitis pigmentosa (a minority of such people have genetic Problems of retinal phosphodiesterases); if prescribed, this should be finished with caution.

Merk: Beslutninger om behandling vurderes i fellesskap av forskriver og pasient under konsultasjonen. Den endelige avgjørelsen vil imidlertid alltid være forskriverens.

People today with “crowded” optic disc are also thought of at better hazard for NAION when compared with the general populace, nevertheless, evidence is insufficient to assistance screening of future end users of PDE5 inhibitors, which includes VIAGRA, for this uncommon issue.

†Irregular Vision: Gentle and transient, predominantly colour tinge to vision, and also greater sensitivity to gentle or blurred eyesight. In these experiments, just one affected individual discontinued on account click here of abnormal vision.

VIAGRA incorporates sildenafil, which is the same medication located in another drug named REVATIO. REVATIO is used to treat a uncommon disorder named pulmonary arterial hypertension (PAH).

The AUC of your Lively metabolite, N-desmethyl sildenafil, was increased 62% by loop and potassium-sparing diuretics and 102% by nonspecific beta-blockers. These consequences on the metabolite aren't envisioned for being of scientific consequence.

i.d.) resulted in a very 63% lower of sildenafil AUC along with a fifty five% decrease in sildenafil Cmax . Concomitant administration of sturdy CYP3A4 inducers, such as rifampin, is expected to result in increased decreases in plasma amounts of sildenafil.